We have some databases with a split front end (stored on local computer) and backend (stored on a server mapped via relative path) using Access 2016 (build 9126.2259). Since upgrading many computers to Windows 10 1803 the backend database constantly becomes corrupt. We have to disable the three caches referenced in the article linked below in order for the corruption to stop, but this makes file server operations much slower while also causing unnecessary network traffic. We never had this issue on Windows 10 1703.

https://docs.microsoft.com/en-us/previous-versions/windows/it-pro/windows-7/ff686200(v=ws.10)